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In recent years, interest in phytochemicals has increased because they have shown high safety for patients in clinical studies compared to synthetic chemicals that have shown high toxicity and a potential to cause some serious health disorders [182, 183]

In Vitro Mechanistic Studies In vitro mechanistic studies elucidate molecular pathways

Kato S, Fukui K, Kirigaya H, Gyotoku D, Iinuma N, Kusakawa Y, Iguchi K, Nakachi T, Iwasawa T, Kimura K (2016) Inhibition of DPP-4 by alogliptin improves coronary flow reserve and left ventricular systolic function evaluated by phase contrast cine magnetic resonance imaging in patients with type 2 diabetes and coronary artery disease