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More fat burned = glycogen spared = longer time to fatigue Especially beneficial for CrossFit, endurance athletes, and metabolic conditioning MOTS-c improves physical performance by regulating mitochondrial respiration and metabolic substrate use. Reynolds et al., Nature Communications Supports Anti-Aging and Stress Resistance Emerging research suggests that MOTSc acts like a mitochondrial stress hormone , improving longevity pathways similar to caloric restriction

Another novel AC5 inhibitor, C90, inhibits cAMP production to FSK by 42% in WT but not in AC5KO, suggesting its selective AC5 inhibitory effect

lncRNA-SNHG14 was significantly upregulated in the nutlin3a-resistant osteosarcoma (OS) cell line NR-SJSA1, which resulted in downregulation of miR-206, upregulation of SLC7A11 expression and inhibition of ferroptosis (Li et al., 2023)

Recent human studies show that even short durations of moderate-intensity exercise (e.g., 15 minutes at ~55% heart rate reserve) can mobilize cytotoxic NK cells into the bloodstream ( dim and CD57 + NK cells, which have been observed to increase after moderate exercise in pediatric hematopoietic stem cell transplant recipients ( + ) remain elevated for more than an hour post-exercise, reinforcing the hypothesis that physical activity may contribute to immune-mediated senolysis ( These findings further support the concept that moderate-intensity exercise not only enhances immune surveillance of NK cells in the context of tumor defense but may also contribute to the clearance of senescent cells, thus playing a role in aging and tissue homeostasis