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Briefly, 10 mg of pulverized muscle was homogenized in MAS buffer containing 70 mM sucrose, 220 mM mannitol, 5 mM KH 2 PO 4 , 5 mM MgCl 2 , 1 mM EGTA and 2 mM HEPES (pH adjusted to 7.4)

Secondly, although many in vitro prediction models with high accuracy are available, generalizing the characteristics of DILI in a single in vitro model and using it for screening and disease prediction is difficult due to the individual variability of DILI (Weaver et al., 2020)

The lunula represents the distal part of the matrix and may be visible as a crescent-shaped structure on the first digits of the hands and feet.4 The nail folds surround the nail proximally, distally, and laterally

Both peptides are generally well tolerated