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Redox-active metal ions and amyloid-degrading enzymes in Alzheimers disease

In contrast, KDS12025 can liberate hippocampal and SNpc astrocytes from the vicious cycle to enter a virtuous cycle of recovering astrocytic Hb levels and decomposing H 2 O 2, which further reduces oxidative stress and accelerates recovery from AD and PD

Sections were fixed with 4% paraformaldehyde, rinsed with PBS, blocked with goat serum (Vector laboratories, CA, USA) for 30 min at room temperature, and incubated with mouse-anti-GSK-3/ monoclonal antibody (SC-7291, 1:50, Santa Cruz, TX, USA) at 4 C overnight