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Costunolide also improved central nervous system parameters, such as serotonin and norepinephrine levels in the hippocampus, indicating its bidirectional effects on the gut-brain axis

306 A similar conclusion was reached in the study of arginase inhibitor CB-1158

Nat Cell Biol (2018) 20:82335

[DOI] [PMC free article] [PubMed] [Google Scholar] 548.Ferreiro A.L., Choi J., Ryou J., Newcomer E.P., Thompson R., Bollinger R.M., Hall-Moore C., Ndao I.M., Sax L., Benzinger T.L.S., et al