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Incorporating in vivo pharmacokinetic data or clinical evidence would enhance scientific rigor

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RTA is conserved among all members of gamma-herpesvirus family such as EBV, rhesus rhadinovirus (RRV), herpesvirus saimiri (HVS), murine herpesvirus 68 (MHV-68), bovine herpesvirus 4, and equine herpesvirus 2, but only the RTAs from gamma-2-herpesviruses (KSHV, HVS, and MHV-68) acts as a lytic replication activator (Sun et al., 1998

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