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MPO activity, a marker for neutrophil presence, and neutrophil counts in the lung were significantly increased by LPS

however, the limitations of the studies conducted to date, including a reliance on animal models, a lack of standardization across studies with regard to reporting methods, and the use of non-powered proof-of-concept studies, all impair the overall strength of the evidence currently available for the use of engineered bacteria in clinical settings (11, 28, 64).Animal Disease Models are Commonly Used

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For all of foregoing reasons, there is a strong likelihood that a longer half-life medicine will diminish these problems with greater efficacy and cost savings