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both antibiotic use and germ-free conditions suppress the expression of CYP7A1 and CYP27A1, key enzymes involved in BA production based on animal mechanistic studies (Chiang and Ferrell, 2019)

In silica-induced fibrosis models, blocking glycolysis or HIF-1 signaling reduces intracellular glycine levels, which correlates with decreased collagen deposition and attenuated fibrotic responses [110]