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Besides the increase of this oxysterol, which acts as a precursor of CDCA, the primary BA synthesized in the mitochondrial alternative pathway, STARD1-mediated cholesterol trafficking results in accumulation of cholesterol in the MIM, which results in far-reaching consequences, such as disruption of mitochondrial physical properties, leading to decreased membrane fluidity that impairs mitochondrial antioxidant defense, illustrated by the depletion of mitochondrial glutathione (GSH) [131135]

Ferroptosis, first described in 2012, is an iron-dependent form of regulated cell death characterized by: (1) accumulation of lipid peroxides and reactive oxygen species (ROS), (2) distinct mitochondrial morphology including shrinkage and cristae reduction, and (3) dependence on iron metabolism (Yao et al., 2021)

Luo et al., 2021)

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