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doi: 10.3390/biom14060650

Resveratrol Attenuates TNF-Alpha-Induced Activation of Coronary Arterial Endothelial Cells: Role of NF-KappaB Inhibition. American Journal of Physiology

10.1016/j.ejphar.2021.174723

Since there are at least three stages of amplification (catalysis by the GPCR and catalytic enzymatic activities of two enzymes), the signal from even a single molecule of ligand is greatly amplified and the response can be robust