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Cytosolic GPx4 is essential for embryonic development and cell survival

Benjamin RJ, McCullough J, Mintz PD, Snyder E, Spotnitz WD, Rizzo RJ, et al

483,484,485 PPAR- agonists (thiazolidinediones and TZDs) used for diabetes mellitus, which enhance adipocyte lipid storage, decrease ectopic lipid accumulation and improve insulin sensitivity in liver and skeletal muscles

Both ME2-inhibitor complexes (ME2-EA and ME2-MDSA) were generated in the presence of the cofactors NAD + and Mg 2+ , the natural substrate pyruvate (PYR), and the inhibitor (EA or MDSA), but the structures demonstrate that only the inhibitor (EA or MDSA) binds to the allosteric regulatory site at the dimer interface (Figs