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Marketing in the 1970s, USST distributed free samples to first time users, instructing seasoned company representatives (reps) to walk novices through the mechanics of placing the pouch between the upper lip and gum, the length of time the pouch should stay before removal, the issue of salivation, and above all, reps were to encourage users not to give up should their first experience(s) be less than pleasant [33]

In certain conditions it may be accompanied by other symptoms such as rhinorrhoea (nasal discharge, which can drip from the front of the nose, or into the back of the throat catarrh), facial pain, anosmia (loss of sense of smell), sneezing, itching and crusting