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Among these, bortezomib is a proteasome inhibitor that induces ROS and ER stress in head and neck squamous cell carcinoma cells 112 , and celecoxib, a nonsteroidal anti-inflammatory drug, aggravates ER stress and induces apoptosis by altering the Bax/Bcl-2 ratio and increasing ROS in prostate cancer cells 113

Increased antioxidant markers (GSH, SOD), and downregulated pro-inflammatory cytokines (IL-6, TNF-, IBA-1, GFAP (Liu et al., 2018)

Studies have shown that glutathione supplementation can increase both red blood cell GSH levels and reduce free radical damage in pregnant women