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159161,163,178 In these four studies, a significantly increased risk of developing vitamin B 12 depletion as a result use of acid-lowering medication was identified and data from the two studies evaluating duration of treatment supported the general assumption that long-term use of these drugs is associated with an elevated risk of deficiency of this vitamin, but the results were not conclusive

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Environ Sci Pollut Res 30(50):108979108991