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Brecka suggests keeping the dosage low to avoid dependency and potential long-term disruption to natural sleep patterns

Bezafibrate rescues mitochondrial encephalopathy in mice via induction of daily torpor and hypometabolic state

Another consideration is whether to target intracellular or extracellular (secreted) expression

BCAA includes Leu, iLe, and valine, and all three amino acids participate in the citric acid cycle by producing acyl-CoA derivatives via branched-chain amino acid transferase (BCAT), branched-chain -keto acid dehydrogenase (BCKDH), which in a subsequent series of reactions produce acetyl-CoA