doi: 10.1016/j.expneurol.2011.01.006 11 El WalyB.MacchiM.CayreM.DurbecP
In people over 60, the prevalence is around 2%.[ref] The lack of vitamin B12, though, can cause symptoms long before developing pernicious anemia
Chapters: 00:00 Intro & Guest Introduction 02:10 Women & Testosterone (Why It Matters) 10:00 Problems With Western Medicine & Hormone Panels 16:30 Perimenopause Symptoms & Hormone Changes 21:15 Skin, Collagen & Anti-Aging Treatments 27:00 Menopause, Diet & Environmental Factors 32:00 Best Peptides for Women 38:00 Hormone Imbalances & Common Symptoms 44:00 Peptides + Hormones for Optimization 49:30 Where to Find Lee & Closing We cover: Women & Testosterone More than libido Testosterone plays a major role in bone health and preventing osteoporosis Supports lean muscle, energy, drive, and longevity Helps women regain motivation, clarity, and vitality Libido improvements are often just a bonus Why bone health matters for women Declining testosterone increases bone breakdown over time Higher risk of osteoporosis as women age DEXA scans can reveal early bone loss before symptoms appear Hormone optimization can help slow or reverse bone density decline How testosterone is administered for women Pellets are a common delivery method lasting about 4 months Bloodwork and lifestyle factors determine dosage Treatment is individualized based on labs, symptoms, and goals Gradual adjustments help avoid overtreatment Common symptoms of hormone imbalance in women Fatigue and lack of motivation Brain fog and depression Low libido Weight gain around the abdomen Irritability and sleep disruption Hot flashes and hormonal shifts during perimenopause Hormones are the foundation of health Testosterone, estrogen, and progesterone must be balanced together Hormonal balance supports heart health, cognition, sleep, and longevity Peptides work best once hormone levels are optimized Peptides Lee recommends for women BPC-157 for inflammation and healing Retatrutide for fat loss and metabolic health GHK-Cu for skin, collagen, and regeneration Glutathione for detoxification and immune support Mitochondrial peptides like MOTS-C and SS-31 for cellular energy Aesthetic longevity strategies Skin-first approach to beauty and aging Lasers and microneedling for skin quality Sculptra to stimulate natural collagen production Radiesse for elastin support and skin tightening Lifestyle still matters Stress management and cortisol control Exercise and muscle preservation Clean nutrition and minimizing environmental toxins Hormones and peptides work best when lifestyle is dialed in The big takeaway: Hormone balance is the foundation
CLOCK is involved in the circadian transactivation of peroxisome- proliferator-activated receptor (PPAR) in mice
