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Notably, XKR8 KO BMNs failed to generate both filamentous chromatin structures and the citrullinated histones, suggesting a disruption in upstream NET signaling, particularly in Ca 2+ signaling pathways, given that peptidylarginine deiminase 4 (PAD4) activation is calcium-dependent 34

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Proportions of responders were 50.1% and 45.4% at week 12, 51.2% and 48.7% at week 24, and 43.7% and 44.5% at week 48 in the glycopyrrolate/eFlow CS and tiotropium groups, respectively