foxo4 dri senolytic or senomorphic Development of a novel by precise disruption of FOXO4-p53 complex CHK2-USP37 axis stabilizes FOXO4 to
CHK2 USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis PNAS Frontiers Senolytic Peptide FOXO4 DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. Targeting cellular senescence with senotherapeutics: senolytics and senomorphics Zhang 2023 The FEBS Journal Wiley Online Library
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