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374 Clinical cohort trials have shown an early reduction in gut microbiota diversity is strongly related to elevated AD risk, 375 and the presence of gut microbiota subspecies such as Clostridium Perfringens , Clostridium difficile and Faecalibacterium prausnitzii is closely associated with reduced capability of producing short-chain fatty acids (SCFAs), while L

These results suggested that LAbs@Lip@BMn/Rapa treatment can effectively restore spatial memory impairments and enhance cognitive performance in AD model mice

In addition, experimental findings also suggest that AChE inhibitors may disrupt the electron transport chain, which could contribute to the generation of ROS and apoptosis of dopaminergic neurons (Hroudov et al., 2011