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Science 257: 14961502 JessopCE,BulleidNJ (2004) Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells

244 Upon pressure overload, lysosomal deoxyribonuclease (DNase) II deficiency in cardiomyocytes leads to mtDNA accumulation in autolysosomes, which subsequently activates TLR9 signaling-mediated inflammatory responses, contributing to heart failure