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These 15 altered metabolomics pathways resulted in increased levels of glutamate, 4-Aminobutanoate, carnosine, thymine, porphobilinogen, homogentisate and 4-Guanidinobutanoate in the R group ( Figure 5B , Supplementary Figure 4A )

The role of curcumin as an anti-inflammatory agent involves the downregulation of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-) and interleukin-1 (IL-1)

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

Numerous studies have found that naturally occurring peptides showed antihypertensive activity through different action mechanisms and could be an effective ingredient for hypotension ( These action mechanisms can be classified into two types: renin-angiotensin system and kinin-arginine-nitric oxide system (Figure 8)