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The reciprocal changes in D2 and D3 are shown in elegant studies demonstrating that D2 is induced to allow proper differentiation after muscle injury, while D3 induction in proliferating muscle cells protects against excessive local thyroid hormone concentrations, preventing apoptosis (106, 214)

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The physiological role of Treg cells is to maintain immune tolerance by suppressing effector T-cell activity and preventing inappropriate immune responses