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[22] : 3 John Camden Hotten's 1859 Dictionary of Modern Slang, Cant, and Vulgar Words likewise states that it originated in the 1840s ("about twelve or fifteen years ago"), but with "chaunters" and "patterers" in the Seven Dials area of London

The study found methylation changes in cells taken from people who smoked, including cheek (which are directly exposed to smoke), cervical (which arent) and blood cells

Aerosol contains harmful substances including, nicotine, a carcinogenic chemical called diacetyl, volatile organic compounds, cancer-causing chemicals, and heavy metals such as nickel, tin, and lead

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