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[36] conducted a historical cohort study of patients referred to an urban academic medical center

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These include: In extreme cases, symptoms include: Serious or fatal nicotine overdoses Nicotine affects the body in a variety of ways

Irritation is also markedly reduced. According to the tobacco industry definition, harshness is a chemically induced physical effect associated with a roughness, rawness experience generally localised in the mouth and to a lesser degree in the upper reaches of the throat and the trachea due to inhalation of tobacco smoke