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The first cigarette company to use physicians in their ads was American Tobacco, maker of Lucky Strikes

Filters were introduced to address health concerns in the 1950s

In fact, much more research is required to establish whether pure nicotine has detrimental or good effects, although it can be stated that many of the consequences induced by cigarette smoke, particularly in respiratory problems, are caused by other components in cigarette smoke

In addition, cells contain certain proteins (spell-checkers and proof-readers) that make sure that there are no spelling errors, or mutations in the nucleotide sequence before DNA replication