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All feedback received on or before Wednesday, August 31, 2016, will be considered in developing a regulatory proposal under the Tobacco Act for plain and standardized package and product requirements (see Appendix B for an overview of the federal regulatory process)

Indeed, the use of extreme conditions increases the likelihood of eliciting a response, potentially allowing for small effects to be observed that would otherwise be missed or represented as no result and also allowing comparisons to combustible cigarettes via EC 50 values

Smoking and psychopathology increasingly associated in recent birth cohorts

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