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Flavor: It is the special note given by each type of tobacco, thanks to its curing or drying, and in the case of blends, by the greater or lesser harmony achieved when making them

INTRODUCTION Since the emergence of electronic nicotine delivery systems (ENDS), commonly known as e-cigarettes, in the mid-2000s, there has been growing public concern about their health effects and increasing usage rates, particularly among adolescents 1

However, because the inverse-variance weighted method is sensitive to invalid instrumental variables and pleiotropy 25 , several sensitivity analyses were additionally performed, including weighted median, MR Egger, MR-Egger-SIMEX and MR-PRESSO

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