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Although it is difficult to perform measurement of ROS due to its short half-life, there are some clinical studies that showed increased levels of F2 isoprostanes as well as 8-isoprostanes in urine samples form smokers compared with non-smokers 105 and in patients with osteoporosis, revealing the oxidative stress occurrence

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Both ORF1 and 2 show homology to the CP-preceding HP of IFA65, but also to the HPs of SYM and Mlo7

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