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Smoking-Induced Oxidative Stress in Bone: The Effects on Bone Turnover Jlia Benini Kohler 1 , Jader Joel Machado Junqueira 1 , Taysa Cristiane Moreira da Silva 3 , Marco Antonio Gonalves Pontes Filho 3,4 , Iolanda De Ftima L C Tibrio 1 , Fernanda Degobbi T Q S Lopes 1 , Alexandre Pvoa Barbosa 1,2* 1 Department of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of Sao Paulo, Sao Paulo, Brazil 2 Department of Orthopaedics, Hospital do Corao - SP Brazil 3 Department of Rheumatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil 4 Departments of Orthopaedics and Rheumatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil Abstract Despite of clinical evidence of increased incidence of bone diseases amongst smokers as well as worsening recovery in orthopedic surgeries, it is still unclear which pathological mechanisms are induced by smoking and how these events impair bone turnover