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29 The convergence of these danger signals informs the DC about inhaled material that poses an immediate threat to pulmonary tissues and activates a maturation program: DCs process sampled antigen, present it on major histocompatibility (MHC) molecules, and strongly increase T-cell costimulatory molecule expression on their surface

Once major brands settled on 20 as their standard, competitors followed to stay comparable on shelf and the number became an informal industry benchmark that regulators and manufacturers alike built later standards around

Cheap SC cigarettes sold on neighborhood streets undermine youth smoking prevention efforts in affected states

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