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As of late 2021, Florida Statute Section 569.32(1)(a) requires that any person or entity that seeks to sell nicotine products, which includes e-cigarettes and vapes, must obtain a retail nicotine products dealer permit for each place of business or premises at which nicotine products are sold

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In support of the findings described above, LPS and nicotine were reported to stimulate osteoclast formation in osteoclast precursor RAW 264.7 cells [25] and primary non-adherent bone marrow cells through direct enhancement of receptor activator of NF-kappaB ligand (RANKL) expression [27] and suppression of Osteoprotegerin (OPG) expression [28, 29]

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