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A separate study found similar results suggesting an increase in MUC5AC protein levels in culture human bronchial epithelial cells exposed to PG:VG aerosols [37] as well as an increase gene expression for several inflammatory markers including cytokines interleukin-6, interleukin-8 and matrix metalloproteinase-9 (MMP-9), known to play a role in the pathogenesis of COPD [37]

The disease is associated with chronic inflammation, which is associated with the onset and progression of COPD, but anti-inflammatory therapy is not first-line treatment

Borland and Savvas [2] note a number of internal tobacco industry studies of sensation transfer that reveal how smokers perceptions of cigarette attributes are impacted by product appearance, such as length and colors