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Apparently, nicotine has the effect of changing VSMCs from differentiated to dedifferentiated type, that is transformation from the contractile-type to the synthetic-like (proliferative) type

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The index isnt good, and you have to double-check all the entries, because the correspondents answers werent always correct

The protective effect was also correlated with greater duration and frequency of smoking.[] Similarly, in a large cohort study that followed 1, 59, 340 women over a 12.7 years period, the authors found that current smokers had reduced risk for all types of thyroid cancer