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Nicotine addiction can become a cycle of dopamine release, withdrawal, and cravings that reinforces continued nicotine use. The tobacco industry profits from keeping this cycle going. What feels like relief is often Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function ScienceDirect What is nicotine withdrawal: symptoms, coping, and treatment Frontiers Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens

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