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These human macrophage populations were also characterized by an increased expression of tissue remodeling and ECM degradation associated markers ( SPP1 , MMP14 , MMP19 , FN1 , PLAUR, IL7R, CTSL, CTSS, CTSK ) although they were not exclusively expressed by C1Q + and mono-like macrophages ( Figure 7B )

Systemic therapies including methotrexate, retinoids, hydroxychloroquine and adalimumab have been used anecdotally but are rarely needed, as most cases respond well to appropriately potent and sustained topical corticosteroid therapy

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