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Folks who are using stimulants, and not intentionally using opioids, are unprepared to respond to an opioid overdose, said Brown University epidemiologist Jaclyn White Hughto, because they dont perceive themselves to be at risk. Hughto is a principal investigator in a new, unpublished study called Preventing Overdoses Involving Stimulants. Hughto and the team surveyed more than 260 people in Rhode Island and Massachusetts who use drugs, including some who manufacture and distribute stimulants such as cocaine

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Some of these drugs also have anticholinergic effects, which, as mentioned above, can add to Benadryls side effects