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These facts, along with biomedical research linking vaping to multiple adverse health effects, make the recent precipitous increase in e-cigarette use among youth particularly alarming. Baker added, Our synthesis of evidence regarding the role of non-menthol flavors in e-cigarettes on product perceptions and use is particularly relevant to the FDAs recently proposed policy framework that seeks to place additional regulations on the sale of non-menthol-flavored e-cigarettes to youth. This new BMJ Open review significantly expands earlier findings about e-cigarettes and flavors