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1B, smokers have a partial deterioration of endothelial function, with a similar severity as in patients with hypercholesterolemia, with the presence of both risk factors (hypercholesterolemia and smoking) leading to a significant and severe deterioration of endothelial function [36]

For instance, a meta-analysis of 28 observational studies involving 13,317 men found that smokers had higher mean total testosterone levels (1.53 nmol/L) compared to non-smokers

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