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B., Oas-Terpstra, J

Addiction as a systems failure: focus on adolescence and smoking

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1 Introduction Atopic dermatitis (AD) is a prevalent chronic relapsing inflammatory skin disorder, clinically characterized by intense pruritus, eczematous lesions, and impaired skin barrier function, all of which significantly diminish patients quality of life ( Recent evidence suggests that pruritus in AD is not merely a unidirectional response of sensory neurons to external stimuli, but rather arises from complex neuroimmune interactions that sustain pathological signaling ( This review provides a comprehensive overview of the mast cellneuron axis in AD-related chronic pruritus, with emphasis on its structural basis, molecular pathways, and translational relevance for targeted therapeutic development