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GLP-1RAs Acting Through cAMP/PKA/NFkB Signaling Pathways The GLP-1 receptor functions as a stimulatory G-protein that activates the guanine nucleotide binding proteins (G proteins), specifically through the G protein alpha subunit group S (G s ) signaling cascade to increase cyclic adenosine monophosphate (cAMP) accumulation and activate protein kinase A (PKA)

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