of Biol., & Center for Muscle Biology, Univ
this risk is more of concern for users who are inexperienced or do not use protective gear.[126] Users can adjust the voltage of some e-cigarettes.[126] The amount of vapor produced is controlled by the power of the battery, which has led some users to adjust their e-cigarettes to increase battery power to obtain a stronger nicotine "hit", but there is a small risk of battery explosion.[24] Some users add more or larger batteries to nonadjustable e-cigarettes, which may lead to battery leakage or explosion.[126] The FDA stated to only use batteries recommended for use with the device.[18] The FDA recommended to replace the batteries if they get damaged or wet.[18] The extent to which teens are altering e-cigarettes, such as dripping the liquids onto the atomizer to get more nicotine intake, is not known.[17] Case reports related to health effects Nicotine Pregnant women, breastfeeding mothers, and the elderly are more sensitive to nicotine than other individuals.[19] There are safety issues with the nicotine exposure from e-cigarette use, which may cause addiction and other adverse effects.[20] Nicotine is regarded as a potentially lethal poison.[13] Concerns exist that vaping can be harmful by exposing users to toxic levels of nicotine.[13] At low amounts, it has a mild analgesic effect.[19] At sufficiently high doses, nicotine may result in nausea, vomiting, diarrhea, salivation, bradyarrhythmia, and possibly seizures and hypoventilation.[131] High doses can induce deleterious effects on the growth of osteoblasts.[132] Higher-doses leads to loss of nicotinic receptor specificity and induces cholinergic toxicity.[85] The highest-doses can lead to coma.[85] However, at the low amount of nicotine provided by e-cigarettes fatal overdose from use is unlikely
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