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Hallmark features include lipid layer depletion and the downregulation of key structural proteins such as filaggrin, claudin-1, loricrin, and Zonula Occludens-1 (ZO-1) ( Furthermore, neuropeptides released from sensory nerves, such as substance P (SP) and calcitonin gene-related peptide (CGRP), stimulate keratinocytes to produce proinflammatory cytokines including IL-1, IL-6, and TNF ( + influx and the activation of transient receptor potential (TRP) channels ( 2.2 Crosstalk with cutaneous microbial dysbiosis As a barrier-associated ecological niche, the skin microbiota plays a pivotal role in maintaining hostmicrobial homeostasis

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