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Nucleo-cytosolic -KG is an important co-factor for several chromatin-modifying enzymes, including histone demethylases and the Ten-Eleven-Translocation (TET) family enzymes that regulate DNA demethylation [72]

[DOI] [PMC free article] [PubMed] [Google Scholar] 197.Srivastav S., Neupane S., Bhurtel S., Katila N., Maharjan S., Choi H., Hong J.T., Choi D.Y

GSCs are derived from the malignant transformation of normal neural stem cells or the dedifferentiation of tumor cells after radiotherapy or chemotherapy (225,226)