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[9] In The Hasheesh Eater (1857), American author Fitz Hugh Ludlow was one of the first to describe in modern terms the desire to change one's consciousness through drug use: [D]rugs are able to bring humans into the neighborhood of divine experience and can thus carry us up from our personal fate and the everyday circumstances of our life into a higher form of reality

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7.2b Bupropion Sustained-Release (SR) Although bupropion is an inhibitor of dopamine and norepinephrine reuptake, its mechanism in smoking cessation is still not well understood