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The person would then develop the following symptoms: Jaundice (yellow eyes and skin) Haematemesis (vomiting blood) Bleeding in the gut Easy bruising Fatigue, weakness and loss of appetite Ascites (swollen abdomen due to excess fluids) Oedema (swelling of ankles due to effect on the kidneys) Itching all over the body Increased sensitivity to alcohol and drugs, both medical and recreational (because the liver cannot process them) The risk of death from liver failure is very high as the liver stops working completely

It occurs when they take more frequent and deeper puffs to satisfy their cravings

The design formula was constructed to test for the effect of treatment while controlling for donor

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