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For each historical time point, t , we applied S-map 34 to predict macroinvertebrate community abundance, species richness, and species abundance at t + 1 using a small increase (+ Z /2) and decrease ( Z /2) in each environmental variable, Z ( t ), thereby estimating the local response (i.e., state-dependent sensitivity) of the response variable to each driver

A secondary analysis disaggregated the current e-cigarette use only group by smoking history to distinguish exclusive e-cigarette users who had never smoked from those who were former smokers