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These are principally caused by the chemicals released when tobacco is burned at a temperature of 600C

Severe exacerbation of COPD after diagnosis was defined as in-patient or emergency room visit with one of the following ICD-10 codes as the principal or secondary diagnosis: COPD (J43.X [except J43.0] or J44.X) or COPD-related disease (pneumonia [J12.XJ17.X], pulmonary thromboembolism [I26, I26.0, or I26.9], dyspnea [R06.0], or acute respiratory distress syndrome [J80]), and a prescription for systemic steroids or antibiotics at the same visit [19]

Using a survey conducted in stages with varying levels of sampling probabilities, the NHANES project evaluated the health and nutritional situation of non-institutionalized Americans (14)