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[2] This settlement included payments to states, restrictions on advertisements, and free access to internal industry research, although some have criticized the settlement for shielding the industry from future lawsuits, granting a monopoly to the largest tobacco companies, creating "client states" dependent on settlement payments, and shifting the cost of cigarettes to individual smokers rather than companies

Classic emphysema with the greatest severity in the lower lobes has been described among adults with the PI *Z allele and COPD, but diffuse or upper lobe emphysema can also be observed in this population (Parr et al

Are They Safer Than Cigarettes