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Possibly, the two factors could be working together to cause vascular changes in the body, interrupting the blood supply to the brain, according to the study, published in the journal Neurology and reported in Bioscience Technology ( According to Teshamae Monteith, a doctor and one of the authors from the University of Miami, Miller School of Medicine, "One possible mechanism of increased stroke risk may be oxidative stress, which has been theorized to have a role in migraine and may lead to increased susceptibility to vascular events among active smokers." While migraines themselves did not signal a greater risk of stroke, smokers who also had migraines were three times as likely to have a stroke, said the researchers in the Northern Manhattan Study