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DAVID analysis of downregulated proteins yielded six significant clusters, which included extracellular matrix, cell adhesion/migration, fibronectin, endoplasmic reticulum, actin cytoskeletal signaling, and actin filament binding, implicating the cytoskeleton as a major target (Fig

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Some causes include: Burning of the tissue from extremely hot temperature or acidity Stress Sharp teeth, braces, ill-fitting dentures Cigarette smoking Allergies Underlying health condition Symptoms: Small shallow round ulcer that is gray, white, or yellow and can be surrounded by redness Painful sore that can appear anywhere in the mouth such as the tongue, gums, cheek, or palate May have accompanying symptoms of sluggishness or lethargy, fever, diarrhea, joint/body pain, a rash, swollen lymph nodes Treatment Canker sores typically clear on their own within 1-2 weeks